The effect that metronidazole induces the micronucleus of root tip cells in Vicia faba was mainly studied in this experimentation. By this study, it showed that: (1) When the metronidazole concentration was 0.1 mg/L, 6 mg/L, 12 mg/L, 40mg/L and 500 mg/L, the micronucleus frequencies of root tip cells in Vicia faba was significantly different from that of negative control group, and there was apparent dosage—effect relationship between the concentration of metronidazole and the micronucleus frequencies of root tip cells in Vicia faba；(2) Metronidazole could cause the damage of genetical materials (DNA), and it had the characteristic of molecular mutagenesis.
LI Hong
. Research on the Micronucleus of Root Tip Cells in Vicia faba Induced by Metronidazole[J]. Subtropical Plant Science, 2011
, 40(04)
: 56
-58
.
DOI: 10.3969/j.issn.1009-7791.2011.04.013
[1] 李明,等. 甲硝唑静滴致白细胞、血小板减少[J]. 药物不良反应杂志, 2000,2(1): 519.
[2] 闫长福. 甲硝唑致哮喘样发作1例[J]. 中国医院药学杂志, 1998,18(1): 45.
[3] 周世良,等. 静脉滴注甲硝唑致急性肺水肿死亡1例[J]. 中国医院药学杂志, 1998,18(11): 524-525.
[4] 颜京. 甲硝唑致眼部变态反应1例[J]. 中国医院药学杂志, 2000,20(5): 300.
[5] 仪慧兰,等. SO2对蚕豆根尖细胞微核的诱导作用[J]. 生态学报, 2003,23(2): 292-296.
[6] 仪慧兰,等. SO2体内衍生物诱发蚕豆根尖细胞微核[J]. 生态学报, 2004,24(2): 368-371.
[7] Kanaya N, et al. Vicia faba chromosomal aberration assays[J]. Mutat Res., 1994,310: 231- 247.
[8] 李宏,等. 蚯蚓浸膏对环磷酰胺诱发的蚕豆根尖细胞变异的保护作用[J]. 西南师范大学学报(自然科学版), 1997,22(6): 675-679.
[9] Degrassi F, et al. Mirconucleus test in Vicia faba tips to detect mutagen damage in fresh-water pollution[J]. Mutat Res., 1982,13(2): 19-33.
[10] Grant W F. Higher plant assays for the detection of chromosomal aberrations and gene mutations—a brief historical background on their use for screening and monitoring environmental chemicals[J]. Mutat Res., 1999,426(1): 107-112.
[11] Duan C Q, et al. Cytogenetical toxical effects of heavy metal on Vicia faba and inquires into the Vicia-micronucleus[J]. Acta Bot Sin., 1995,37(1): 14-24.
[12] 陶少武. 初生根长度对蚕豆根尖细胞微核率影响的研究[J]. 广西植物, 2005,25(5): 447-448.
[13] 李宏,等. 表面活性剂诱导蚕豆根尖细胞微核及染色体畸变[J]. 环境与健康杂志, 2005,22(5): 315-316.
[14] 李宏,等. 铬渣堆场渗滤液对蚕豆根尖细胞微核的影响[J]. 亚热带植物科学, 2011,40(2): 10-13.
