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油茶植物化学成分及药理活性研究进展

  • 汪 玥 ,
  • 何恩铭 ,
  • 王雅英 ,
  • 李黎明 ,
  • 刘华欣 ,
  • 黄秀梅 ,
  • 吴 春
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  • 1.厦门医学院,福建省道地药材生物工程重点实验室,福建 厦门 361023;2.福建省亚热带植物研究所,福建省亚热带植物生理生化重点实验室,福建 厦门 361006
汪玥,本科生,药学专业。

收稿日期: 2017-09-16

  修回日期: 2017-11-07

  网络出版日期: 2017-12-29

基金资助

厦门市科技计划项目(No. 3502Z20151230);厦门医学院大学生创新创业项目(201712631007)

Advances on Chemical Constituents and Pharmacology of Camellia oleifera

  • WANG Yue ,
  • HE En-ming ,
  • WANG Ya-ying ,
  • LI Li-ming ,
  • LIU Hua-xin ,
  • HUANG Xiu-mei ,
  • WU Chun
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  • 1.Fujian Provincial Key Laboratory of Genuine Regional Drug Bio-engineering, Xiamen Medical College, Xiamen 361023, Fujian China; 2.Fujian Key Laboratory of Physiology and Biochemistry for Subtropical Plant, Fujian Institute of Subtropical Botany, Xiamen 361006, Fujian China

Received date: 2017-09-16

  Revised date: 2017-11-07

  Online published: 2017-12-29

摘要

油茶Camellia oleifera为我国特有的油料植物,具有较高的食用和药用价值。油茶中主要包括三萜及其皂苷类、黄酮类、木脂素类、多酚类、多糖类化合物等成分;药理研究表明,油茶具有抗菌消炎、抗肿瘤、抗氧化、降血脂、降血糖等功效。本文对近年来油茶化学成分及药理活性研究进行梳理、归纳,以期为油茶进一步研究、开发提供参考。

本文引用格式

汪 玥 , 何恩铭 , 王雅英 , 李黎明 , 刘华欣 , 黄秀梅 , 吴 春 . 油茶植物化学成分及药理活性研究进展[J]. 亚热带植物科学, 2017 , 46(4) : 394 -400 . DOI: 10.3969/j.issn.1009-7791.2017.04.020

Abstract

Camellia oleifera, which has high edible and medicinal value, is the particular plant in China. From the phytochemical view, the second metabolites such as terpenoids and their saponins, flavonoids, polyphenols, polysaccharides and protein-class components had been reported from this species. Pharmacological research showed that C. oleifera had many efficacy, including anti- inflammatory, antineoplastic, antioxidant, hypolipidemic and hypoglycemic activities. In this paper,the chemical components and pharmacology of C. oleifera were reviewed to provide references for its further development and utilization.

参考文献

[1] 高继银. 山茶属植物主要原种彩色图集[M]. 杭州: 浙江科学技术出版社, 2005: 15—16.

[2] 国家药典委员会. 中华人民共和国药典(一部)[M]. 北京: 化学工业出版社, 2015: 411.

[3] 那婧婧,李玲,邹莉,卢芳国,赖琼玮,裴建儒,张世鹰,陈建松. 油茶粕及其中药复方抗菌及去垢作用研究[J]. 中医学报, 2016,31(5): 704—706.

[4] 马丽媛,李林,唐玲,陈跃龙,冯宝民,史丽颖,王永奇. 油茶的粕、果皮和叶的抗肿瘤活性研究[J]. 华西药学杂志, 2012,27(1): 8—12.

[5] Li X, Zhao J, Peng C, Chen Z, Liu Y, Xu Q, Khan I A, Yang S. Cytotoxic triterpenoid glycosides from the roots of Camellia oleifera[J]. Planta Medica, 2014,80(7): 590—598.

[6] 唐伟卓,赵余庆. 油茶皂苷的现代药学及生物活性研究进展[J]. 药物评价研究, 2012,35(1): 53—57.

[7] 王玲琼,徐巧林,董丽梅,张强,谭建文. 油茶果壳化学成分研究[J]. 热带亚热带植物学报, 2017,25(1): 81—86.

[8] 焦玉兰,付辉政,周国平,罗跃华,王栋,鄢庆伟,钟瑞建. 油茶茎中1个新的三萜皂苷[J]. 中草药, 2016,47(15): 2592—2596.

[9] 鄢庆伟. 油茶化学成分研究[D]. 南昌: 南昌大学硕士学位论文, 2016.

[10] Yan Q W, Fu H Z, Luo Y H, Zhou G P, Wan K H, Zhong R J. Two new triterpenoid glycosides from the stems of Camellia oleifera Abel[J]. Natural Product Research, 2016,30(13): 1484—1492.

[11] 吴江平. 油茶根中皂苷类化学成分及其抗肿瘤活性的研究[D]. 苏州: 苏州大学硕士学位论文, 2016.

[12] 鄢庆伟,钟瑞建,周国平,付辉政,张天啸. 油茶茎化学成分研究[J]. 中药材, 2015,38(10): 2102—2104.

[13] 马丽媛,李林,唐玲,陈跃龙,冯宝民,史丽颖,王永奇. 油茶粕正丁醇组分水解产物化学成分的研究[J]. 时珍国医国药, 2011,22(12): 2868—2870.

[14] 宗建法. 油茶籽皂苷分离鉴定及其抗肿瘤细胞增殖活性初步研究[D]. 合肥: 安徽农业大学硕士学位论文, 2015.

[15] Zong J, Wang R, Bao G, Ling T, Zhang L, Zhang X, Hou R. Novel triterpenoid saponins from residual seed cake of Camellia oleifera Abel. show anti-proliferative activity against tumor cells[J]. Fitoterapia, 2015,104: 7—13.

[16] 佟小静,陈重,李夏,李笑然,许琼明,杨世林. 油茶根化学成分的研究[J]. 中草药. 2011,42(10): 1936—1938.

[17] 佟小静. 油茶根化学成分研究[D]. 苏州: 苏州大学硕士学位论文, 2011.

[18] Zhou H, Wang C Z, Ye J Z, Chen H X. New triterpene saponins from the seed cake of Camellia oleifera and their cytotoxic activity[J]. Phytochemistry Letters, 2014,8(1): 46—51.

[19] Fu H Z, Wan K H, Yan Q W, Zhou G P, Feng T T, Dai M, Zhong R J. Cytotoxic triterpenoid saponins from the defatted seeds of Camellia oleifera Abel[J]. Journal of Asian Natural Products Research, 2017, doi: 10.1080/10286020.2017.1343822.

[20] Li X, Zhao J P, Li X R, Liu Y L, Xu Q M, Ikhlas A. Khana, Yang S L. New triterpenoid glycosides from the roots of Camellia oleifera Abel[J]. Helvetica Chimica Acta, 2015,98(4): 496—508.

[21] Yang P, Li X, Liu Y L, Xu Q M, Li Y Q, Yang S L. Two triterpenoid glycosides from the roots of Camellia oleifera and their cytotoxic activity[J]. Journal of Asian Natural Products Research, 2015,17(8): 800—807.

[22] Wu J P, Zhao J P, Liu Y R, Li X R, Xu Q M, Feng Y L, Khan Ikhlas A, Yang S L. Five new triterpenoid saponins from the roots of Camellia oleifera C. Abel with cytotoxic activities[J]. Phytochemistry Letters, 2015,13: 379—385.

[23] Zhang Z Y, Wu J P, Gao B B, Ren H T, Liu Y L, Li X R, Li K P, Xu Q M, Yang S L. Two new 28-nor-oleanane-type triterpene saponins from roots of Camellia oleifera and their cytotoxic activity[J]. Journal of Asian Natural Products Research, 2016,18(7): 1—8.

[24] Wu J P, Kang N X, Zhang M Y, Gao H W, Li X R, Liu Y L, Xu Q M, Yang S L. Oleiferoside W from the roots of Camellia oleifera C. Abel, inducing cell cycle arrest and apoptosis in A549 cells[J]. Journal of Asian Natural Products Research, 2017,19(6): 1—14.

[25] Wang S L, Chen Z, Tong X J, Liu Y L, Li X, Xu Q M, Li X R, Yang S L. Triterpenoids from the Roots of Camellia oleifera C. Abel and their cytotoxic activities[J]. Helvetica Chimica Acta, 2013,96(6): 1126—1133.

[26] Yan Q W, Fu H Z, Luo Y H, Zhou G P, Wan K H, Zhong R J. Two new triterpenoid glycosides from the stems of Camellia oleifera Abel[J]. Natural Product Research. 2016, 30(13): 1484—1492.

[27] 郭会琴,熊晶晶,颜流水,李可心. 高效液相色谱—质谱法测定油茶果壳中5种多酚类化合物的含量[J]. 理化检验(化学分册), 2015,51(11): 1493—1496.

[28] 覃佐东,全沁果,敖艳,夏雄,李治章,罗小芳. 油茶不同部位黄酮的提取及活性研究进展[J]. 科技通报, 2016,32(7): 67—71.

[29] 陈跃龙,冯宝民,唐玲,李红冰,史丽颖,王永奇. 油茶叶的化学成分[J]. 沈阳药科大学学报, 2010,27(4): 292—294.

[30] Gao D F, Xu M, Zhao P, Zhang X Y, Wang Y F, Yang C R, Zhang Y J. Kaempferol acetylated glycosides from the seed cake of Camellia oleifera[J]. Food Chemistry, 2011,124(2): 432—436.

[31] 高进勇,高永平,余炎炎,李欢,卢志萍,卜付军,班龙海. 油茶粕中黄酮化合物的分离鉴定及抗氧化性研究[J]. 食品工业科技[J]. 2017,38(15): 35—44.

[32] 刘晓慧. 油茶籽活性成分抗炎机理研究[D]. 杭州: 浙江大学博士学位论文, 2014.

[33] 陈力. 茶饼粕黄酮苷的提取分离、化学结构表征及生物活性研究[D]. 南昌: 南昌大学硕士学位论文, 2011.

[34] Ye Y, Guo Y, Luo Y T. Anti-Inflammatory and analgesic activities of a novel biflavonoid from shells of Camellia oleifera[J]. International Journal of Molecular Sciences, 2012,13(10): 12401—12411.

[35] Chen Y, Tang L, Feng B, Shi L, Wang H, Wang Y. New bibenzyl glycosides from leaves of Camellia oleifera Abel. with cytotoxic activities[J]. Fitoterapia, 2011,82(3): 481—484.

[36] 邹莉,张世鹰,赖琼玮,李玲,裴健儒,陈劲松,卢芳国. 油茶粕中药复合剂抗菌作用的研究[J]. 中医药导报, 2015,21(24): 29—30, 34.

[37] Ye Y, Yang Q, Fang F, Li Y. The camelliagenin from defatted seeds of Camellia oleifera as antibiotic substitute to treat chicken against infection of Escherichia coli and Staphylococcus aureus[J]. BMC Veterinary Research, 2015,11(1): 214—224.

[38] Jin X C, Ning Y. Antioxidant and antitumor activities of the polysaccharide from seed cake of Camellia oleifera Abel[J]. International Journal of Biological Macromolecules, 2012,51(4): 364—368.

[39] 李慧珍. 油茶粕蛋白质的分离提取、理化性质及体外消化产物的抗氧化性研究[D]. 南昌: 南昌大学硕士学位论文, 2013.

[40] 吴俐,沈恒胜,汤葆莎,杨艺龙,陈君琛. 油茶枝浸提液对茶薪菇菌丝酚类物代谢及抗氧化特性的影响[J]. 中国食品学报, 2016,16(7): 59—64.

[41] Li T T, Zhang H, Wu C E. Screening of antioxidant and antitumor activities of major ingredients from defatted Camellia oleifera seeds[J]. Food Science and Biotechnology, 2014,23(3): 873—880.

[42] 张铁. 油茶皂苷A抗肿瘤作用及其机制研究[D]. 贵阳: 贵阳医学院硕士学位论文, 2015.

[43] 杨萍. 油茶皂苷B抗肿瘤作用及其机制研究[D]. 苏州: 苏州大学硕士学位论文, 2015.

[44] 李婷婷. 油茶籽糖蛋白的分离纯化及其功能活性研究[D]. 无锡: 江南大学硕士学位论文, 2014.

[45] Li J, Wang Z X, Shi D Z. Adult exposure to sasanguasaponin induces spermatogenic cell apoptosis in vivo through increased oxidative stress in male mice[J]. Toxicology and Industrial Health. 2010,26(10): 691—700.

[46] 黄毓秀,邓元荣. 油茶皂苷对小鼠的致突变实验[J]. 海峡药学, 2015,27(6): 30—33.

[47] 唐琦,严家俊. 油茶籽油对大鼠降血脂和预防脂肪肝的影响[J]. 广东化工, 2016,32(1): 36—37.

[48] 李佳兴,潘柳叶,普绍丹,农雪倩,朱明毅,王若琦. 油茶蒲提取物对脂代谢的影响研究[J]. 亚太传统医药, 2016,12(3): 7—8.

[49] 陈秋平. 油茶蒲减肥降脂功能因子研究[D]. 杭州: 浙江大学博士学位论文, 2011.

[50] 张伟云,洪珠凤,陈全成,许长江,王晓禹. 油茶醇提物对2型糖尿病小鼠血糖的作用[J]. 海峡药学, 2017,29(01): 21—24.

[51] 张宽朝,马皖燕,文汉. 油茶籽多糖降血糖作用的初步研究[J]. 食品工业科技, 2014,35(2): 337—339.

[52] 戴甜甜,沈建福. 油茶果壳提取物及分级相对α-葡萄糖苷酶的抑制作用[J]. 食品科学, 2011,32(9): 107—110.

[53] 钱海兵,王祥培. 油茶叶水提物抗凝血及抗血栓形成作用研究[J]. 安徽农业科学, 2010,38(21): 11136—11137.

[54] 王亚利,张小茜,李林福,武秋红,路东波,李文霞,石任兵. 基于抗血栓作用的油茶枯饼药物制备物质量表征分析[J]. 世界科学技术—中医药现代化, 2017,19(3): 516—521.

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