生物碱是广泛存在于生物体内尤其是天然植物中的碱性含氮有机化合物，部分生物碱具有抗心律失常、抗高血压、抗炎以及抗肿瘤等多种生理功能。心律失常是由心脏电生理活动紊乱引起的疾病，是心血管疾病高发病率和死亡率的主要原因，在世界范围内严重威胁人类生命健康。文中综述生物碱在抗心律失常中的作用和分子机制研究进展，并展望其开发应用前景。
Alkaloids are nitrogen-containing organic compounds widely existing in organisms, especially in plants. Some alkaloids have a variety of physiological functions such as anti-arrhythmia, anti-hypertension, anti-inflammation and anti-tumor. Arrhythmia is a disease caused by abnormal electrophysiological activity in the heart rate or rhythm. It is the major cause of high cardiovascular morbidity and mortality. It is a serious threat to human health and lives in the worldwide. This paper reviewed the recent progress about the role and mechanisms of alkaloids on anti-arrhythmia. In addition, the development and utilization prospect of alkaloids were introduced.
[1] 南京大学化学系有机化学教研室. 有机化学(下册)[M]. 北京: 高等教育出版社, 1988.
[2] Wu C S, Tsai Y T, Chao A H, Tsai H J. Comparative risk of ventricular arrhythmia and sudden cardiac death across antidepressants in patients with depressive disorders[J]. Journal of Clinical Psychopharmacology, 2017,37(1): 32–39.
[3] Nattel S, Harada M. Atrial remodeling and atrial fibrillation: recent advances and translational perspectives[J]. Journal of the American College of Cardiology, 2014,63(22): 2335–2345.
[4] Antzelevitch C, Belardinelli L. The role of sodium channel current in modulating transmural dispersion of repolarization and arrhythmogenesis[J]. Journal of Cardiovascular Electrophysiology, 2006,17(S): 79–85.
[5] Coppini R, Ferrantini C, Yao L, Fan P, Del Lungo M, Stillitano F, Sartiani L, Tosi B, Suffredini S, Tesi C, Yacoub M, Olivotto I, Belardinelli L, Poggesi C, Cerbai E, Mugelli A. Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy[J]. Circulation, 2013,127: 575–584.
[6] Hasenfuss G, Schillinger W, Lehnart S E, Preuss M, Pieske B, Maier L S, Prestle J, Minami K, Just H. Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium[J]. Circulation, 1999,99(5): 641–648.
[7] Bers D M, Eisner D A, Valdivia H H. Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport[J]. Circulation Research, 2003,93: 487–490.
[8] Sun X, Wang H S. Role of the transient outward current (Ito) in shaping canine ventricular action potential – a dynamic clamp study[J]. The Journal of Physiology, 2005,564(2): 411–419.
[9] Varro A, Nanasi P N, Lathrop D A. Potassium currents in isolated human atrial and ventricular cardiocytes[J]. Acta Physiologica Scandinavica, 1993,149: 133–142.
[10] Jost N, Acsai K, Horváth B, Bányász T, BaczkóI, Bitay M, Bogáts G, Nánási P P. Contribution of IKr and IK1 to ventricular repolarization in canine and human myocytes: is there any influence of action potential duration?[J]. Basic Research in Cardiology, 2009,104(1): 33–41.
[11] Gintant G A. Two components of delayed rectifier current in canine atrium and ventricle. Does IKs play a role in the reverse rate dependence of class III agents?[J]. Circulation Research, 1996,78(1): 26–37.
[12] Loureno A M, Máximo P, Ferreira L M, Pereira M M A. Indolizidine and quinolizidine alkaloids: structure and bioactivity[J]. Cheminform, 2003,34(28): 233–298.
[13] Yang J, Zhang L, Zhu G, Li L. Separation and enrichment of major quinolizidine type alkaloids from Sophora alopecuroides using macroporous resins[J]. Journal of Chromatography B Analytical Technologies in the Biomedical & Life Sciences, 2014(945-946): 17–22.
[14] Narayana Moorthy N S H, Ramos M J, Fernandes P A. Human ether-a-go-go-related gene channel blockers and its structural analysis for drug design[J]. Current Drug Targets, 2013,14(1): 102–113.
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