非洲马铃果化学成分及其活性最新研究进展

doi:10.3969/j.issn.1009-7791.2019.04.011

亚热带植物科学 ›› 2019, Vol. 48 ›› Issue (04): 359-365.DOI: 10.3969/j.issn.1009-7791.2019.04.011

非洲马铃果化学成分及其活性最新研究进展

仝艳，郑志忠，林毅，明艳林

(1.华侨大学化工学院，福建厦门 361021；2.厦门华侨亚热带植物引种园／厦门市植物引种检疫与植物源产物重点实验室，福建厦门 361002；3.福建省亚热带植物研究所／福建省亚热带植物生理生化重点实验室，福建厦门 361006)

收稿日期:2019-09-25 修回日期:2019-11-05 出版日期:2019-12-30 发布日期:2019-12-30
通讯作者: 明艳林
作者简介:仝艳，硕士研究生，从事生物医药研究。
基金资助:
厦门市科技计划项目(3502Z20172016)；华侨大学研究生科研创新能力培育计划资助项目(17013087019)

Recent Advances in Research Composition and Activity on Voacanga africana

TONG Yan, ZHENG Zhi-zhong, LIN Yi, MING Yan-lin

(1.School of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian China; 2.Xiamen Overseas Chinese Subtropical Plant Introduction Garden／Plant Introduction & Quarantine and Plant Product Key Laboratory of Xiamen City, Xiamen 361002, Fujian China; 3.Fujian Institute of Subtropical Botany／Fujian Provincial Key Laboratory of Subtropical Plant Physiology and Biochemistry, Xiamen 361006, Fujian China)

Received:2019-09-25 Revised:2019-11-05 Online:2019-12-30 Published:2019-12-30
Contact: MING Yan-lin

摘要/Abstract

摘要： 非洲马铃果Voacanga africana是非洲地区用于治疗疟疾、痢疾、儿童痉挛等多种疾病的特有的植物资源。随着近年来非洲马铃果研究的深入，发现其中含有大量生物碱、挥发油、黄酮、单宁、类固醇、萜、强心苷、皂苷、蒽类等化学成分。该植物具有细胞毒性、抗氧化、抗菌、神经保护、抗血管生成等多种药理活性。我国已对非洲马铃果进行引种驯化。文中综述了国内外关于非洲马铃果化学成分及其活性的最新研究进展，为其进一步研究和开发提出建议。

关键词: 非洲马铃果, 化学成分, 生物活性

Abstract: Voacanga africana is unique plant resource used to treat malaria, dysentery, children’s spasm and other diseases in Africa. With the development of the research on V. africana in recent years, it was found that V. africana contained a large amount of alkaloids, volatile oil, flavonoids, tannins, steroids, terpenoids, psychoglycosides, saponins, anthracene and other chemical components. V. africana had cytotoxicity, anti-oxidation, anti-bacterial, nerve protection, anti-angiogenesis and other pharmacological activities. It was successfully introduced and domesticated to China. In this paper, the recent advances on chemical constituents and activities of V. africana were reviewed to provide information for further research and development.

Key words: Voacanga africana, chemical composition, biological activity

中图分类号:

R284

仝艳，郑志忠，林毅，明艳林. 非洲马铃果化学成分及其活性最新研究进展[J]. 亚热带植物科学, 2019, 48(04): 359-365.

TONG Yan, ZHENG Zhi-zhong, LIN Yi, MING Yan-lin. Recent Advances in Research Composition and Activity on Voacanga africana[J]. Subtropical Plant Science, 2019, 48(04): 359-365.

参考文献

[1] Tan P V, Penlap V B, Nyasse B, Nguemo J D B. Anti-ulcer actions of the bark methanol extract of Voacanga africana in different experimental ulcer models in rats[J]. Journal of Ethnopharmacol, 2000,73(3): 423—428.
[2] 中国科学院华南植物园. 药用植物:非洲马铃果[EB/OL]. http://www.cas.cn/kxcb/kpwz/201301/t20130105_3731654. shtml.
[3] Tan P V, Nyasse B. Anti-ulcer compound from Voacanga africana with possible histamine H2 receptor blocking activity[J]. Phytomedicine, 2000,7(6): 509—515.
[4] Muoghalu J I. Tree species population dynamics in a secondary forest at Ile-Ife, Nigeria after a ground fire[J]. African Journal of Ecology, 2007,45(1): 62—71.
[5] Gangoue P J, Pegnyemb D E, Niyitegeka D, Nsangou A, Eze N, Minyem C, Mbing J N, Ngassam P, Tih R G, Sodengam B L, Bodo B. The in-vitro antimicrobial activities of some medicinal plants from Cameroon[J]. Annals Tropical Medicine and Parasitology, 2006,100(3): 237—243.
[6] 刘韶松,童庆宣,郑志忠,陈良华,康炼常,郑远斌,明艳林. 非洲马铃果种子的化学成分含量测定和生物活性研究[J]. 亚热带植物科学, 2014,43(2): 98—102.
[7] Quevauviller A, Goutarel R, Janott M M. Preliminary pharmacodynamic data on total alkaloids of Voacanga apocynacea[J]. Annals Pharmaceutiques Francaises, 1955,13(6): 423—424.
[8] La Barre J, Gillo L. Cardiotonic properties of a new alkaloid extract from Voacanga africana: voacaline[J]. Comptes Rendus des Séances de la Société de Biologie et de Ses Filiales, 1956,150(8-9): 1628—1630.
[9] 康炼常,林德钦,郑志忠,明艳林,童庆宣. 非洲马铃果化学成分及其生物活性研究进展[J]. 中药材, 2012(11): 1877—1881.
[10] Kitajima M, Iwai M, Kikura-Hanajiri R, Goda Y, Lida M, Yabushita H, Takayama H. Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity[J]. Bioorganic Medicinal Chemistry Letters, 2011,21(7): 1962—1964.
[11] Kombian S B, Saleh T M, Fiagbe N I, Chen X H, Akabutu J J, Buolamwini J K, Pittman Q J. Ibogaine and a total alkaloidal extract of Voacanga africana modulate neuronal excitability and synaptic transmission in the rat parabrachial nucleus in vitro[J]. Brain Research Bulletin, 1997,44(5): 603—610.
[12] Oliver-Bever B. Medicinal Plants in Tropical West Africa[M]. London: Cambridge University Press, 1986.
[13] Al M A A G. Phytochemical survey and pharmacological activities of the indole alkaloids in the genus Voacanga thouars (Apocynaceae)-An update[J]. Pharmacogn Review, 2009,5(3): 143—153.
[14] Pegnyemb D E, Ghogomu R T, Sondengam B L. Minor alkaloids from the seeds of Voacanga africana[J]. Fitoterapia, 1999,70(4): 446—448.
[15] Rao K V. Alkaloids of Voacanga africana Stapf. Ⅰ. voacafrine and voacafricine—two new alkaloids[J]. The Journal of Organic Chemistry, 1958,23: 1455—1456.
[16] Thomas D W, Biemann K. The hydroxyindolenine derivative of voacangine, a new indole alkaloid from Voacanga africana[J]. Tetrahedron, 1968,24(11): 4223—4231.
[17] Jenks C W. Extraction studies of Tabernanthe iboga and Voacanga africana[J]. Journal of Natural Product Letter, 2002,16(1): 71—76.
[18] Renner U. Voacamidin and voacristin, two new alkaloids from Voacanga africana Stapf.[J]. Experientia, 1957,13(12): 468—469.
[19] Stockigt J, Pawelka K H. Indole alkaloids from cell suspension cultures of Stemmadenia tomentosa and Voacanga africana[J]. Planta Medicine, 1982,45(3): 155.
[20] Renner U, Prins D A. Voacanga alkaloids. Ⅴ. relationship of vobasine to dregamine and tabernaemontanine[J]. Experientia, 1961,17: 209.
[21] 苏艳红,陈晓春,白珂珂,刘海峰,李晖. 伏康树籽挥发油的GC-MS分析[J]. 药物分析杂志, 2011(3): 496—498.
[22] Leal M B, Michelin K, Souza D O, Elisabetsky E. Ibogaine attenuation of morphine withdrawal in mice: role of glutamate N-methyl-D-aspartate receptors[J]. Progress in Neuro-psychopharmacology & Biological Psychiatry, 2003,27(5): 181—194.
[23] Kunesch N, Miet C, Troly M, Poisson J. Alkaloids of Voacanga. 8. Alkaloids of leaves and seeds of Voacanga africana Stapf.[J]. Annales Pharmaceutiques Francaises, 1968,26(1): 79—86.
[24] Kunesch N, Das B C, Poisson J. Voacanga alkaloids. Ⅶ. Structure of voaphylline[J]. Bulletin de la Société Chimique de France, 1967(6): 2155—2160.
[25] Puisieux F, Devissaguet J P, Miet C, Poisson J. Alkaloids of Voacanga. Ⅴ. N-oxy-voacamine[J]. Bulletin de la Société Chimique de France, 1967(1): 251—253.
[26] Carroll P R, Starmer G A. Studies on the pharmacology of conopharyngine, an indole alkaloid of the voacanga series[J]. British Journal Pharmacol Chemother, 1967,30(1): 173—185.
[27] Renner U, Prins D A. Voacanga alkaloids. Ⅳ. Structure of voacryptin and voacristine[J]. Experientia, 1961,17(3): 106.
[28] Chen H M, Yang Y T, Li H X, Cao Z X, Dan X M, Mei L. Cytotoxic monoterpenoid indole alkaloids isolated from the barks of Voacanga africana Staph.[J]. Natural Product Research, 2016,30(10): 1144—1149.
[29] Nair C P P. Lochnericine - a new alkaloid from Lochnera rosea[J]. Tetrahedron, 1959,6(5): 89—91.
[30] Harada M, Asaba K N, Iwai M, Kogure N, Kitajima M, Takayama H. Asymmetric total synthesis of an iboga-type indole alkaloid, voacangalactone, newly isolated from Voacanga africana[J]. Organic Letters, 2012,14(22): 5800—5803.
[31] Mei L, Deng Y, Li F, Guo D L, Lu C Y. Study on the alkaloids constituents from Voacanga africana[J]. Journal of Chinese Medicinal Meterials, 2012,35(2): 226—229.
[32] Ding C F, Ma H X, Yang J, Qin X J, Njateng G S S, Yu H F, Wei X, Liu Y P, Huang W Y, Yang Z F, Wang X H, Luo X D. Antibacterial indole alkaloids with complex heterocycles from Voacanga africana[J]. Organic Letters, 2018,20(9): 2702—2706.
[33] 徐英. 苯并噻唑类衍生物降血糖活性的构效关系研究及Cs2CO3介导的tabersonine的酯交换[D]. 济南: 山东大学硕士学位论文, 2016.
[34] 王荣,李多伟. 高效液相色谱法测定不同方法提取非洲马铃果中的柳叶水甘草碱[J]. 中成药, 2012(7): 1391—1393.
[35] Liu X, Yang D L, Liu J J, Ren N. Analysis of essential oils from Voacanga africana seeds at different hydrodistillation extraction stages: chemical composition, antioxidant activity and antimicrobial activity[J]. Natural Product Research, 2015,29(20): 1950—1953.
[36] Tona L, Kambu K, Ngimbi N, Cimanga K, Vlietinck A J. Antiamoebic and phytochemical screening of some Congolese medicinal plants[J]. Journal of Ethnopharmacol, 1998,61(1): 57—65.
[37] 岳加蕊. 傣药宾蒿和非洲马铃果的化学成分研究[D]. 昆明: 云南中医学院硕士学位论文, 2013.
[38] 周晶,刘佳佳,吴义强,袁广明. 非洲马铃果果籽提取物的体外抗肿瘤活性[J]. 亚热带植物科学, 2017,46(2): 113—116.
[39] 白雅竹,郑志忠,陈清智,黄雯,陈良华,林河通,明艳林. 非洲马铃果 4 种吲哚类生物碱的体外抗肿瘤效果[J]. 亚热带植物科学, 2019,48(3): 209—214.
[40] Mair C E, de Miranda S C, Grienke U. Pharmacokinetics of hERG channel blocking voacangine in wistar rats applying a validated LC-ESI-MS/MS method[J]. Planta Medicine, 2016,82(11-12): 1030—1038.
[41] Kai T, Zhang L, Wang X, Jing A, Zhao B, Yu X, Zheng J, Zhou F. Tabersonine inhibits amyloid fibril formation and cytotoxicity of Abeta(1-42)[J]. Acs Chemical Neuroscience, 2015,6(6): 879—888.
[42] Currais A, Chiruta C, Goujon-Svrzic M, Costa G, Santos T, Batista M T, Paiva J, Madureira M C, Maher P. Screening and identification of neuroprotective compounds relevant to Alzheimer’s disease from medicinal plants of S. Tomé e Príncipe[J]. Journal of Ethnopharmacology, 2014,155(1): 830—840.
[43] Terada Y, Horie S, Takayama H, Uchida K, Tominaga M, Watanabe T. Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree[J]. Journal of Natural Products, 2014,77(2): 285—297.
[44] Kim Y, Jung H J, Kwon H J. A natural small molecule voacangine inhibits angiogenesis both in vitro and in vivo[J]. Biochemical Biophysical Research Communications, 2012,417(1): 330—334.
[45] Lo M W, Matsumoto K, Iwai M, Tashima K, Kitajima M, Horie S, Takayama H. Inhibitory effect of Iboga-type indole alkaloids on capsaicin-induced contraction in isolated mouse rectum[J]. Journal of Natural Medicines, 2011,65(1): 157—165.
[46] 肖春芬,杨成叶,苏艳萍. 治疗药物成瘾植物非洲马铃果种子萌发的初步研究[J]. 种子, 2013(5): 100—101.
[47] 明艳林,黄熙,林德钦,任平,郑志忠,薛梅,梁诗,刘韶松,陈良华,童庆宣. 非洲药用植物引种及新中药创制[C]//中国中西医结合学会. 第二届国际抑郁共病暨第十二届中国中西医结合基础理论学术研讨会论文集. 南京, 2016.

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非洲马铃果化学成分及其活性最新研究进展

Recent Advances in Research Composition and Activity on Voacanga africana

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