亚热带植物科学 ›› 2025, Vol. 54 ›› Issue (6): 698-713.DOI: 10.3969/j.issn.1009-7791.2025.06.012

• 综述 • 上一篇    下一篇

橘皮黄酮对心脏的保护作用及其机制研究进展

吴美芳1,刘昕宇2,李惠华1,叶秋萍1,王  1,陈良华1*   

  1. (1. 福建省亚热带植物研究所 / 福建省亚热带植物生理生化重点实验室,福建 厦门 3610062. 厦门医学院,福建 厦门 361023)
  • 收稿日期:2025-05-17 接受日期:2025-07-15 出版日期:2025-12-31 发布日期:2025-12-31
  • 通讯作者: 陈良华
  • 基金资助:

    厦门市自然科学基金面上项目(3502Z202373082);厦门市技术开发(委托)合同(2025350204001074);厦门市科技计划项目(3502Z20222004)

Research Progress on the Cardioprotective Effects and Mechanisms of Flavonoids in Citrus Peel

WU Mei-fang1, LIU Xin-yu2, LI Hui-hua1, YE Qiu-ping1, WANG Jie1, CHEN Liang-hua1*   

  1. (1. Fujian Institute of Subtropical Botany / Fujian Key Laboratory of Physiology and Biochemistry for Subtropical Plant, Xiamen 361006, Fujian China; 2. Xiamen Medical College, Xiamen 361023, Fujian China)
  • Received:2025-05-17 Accepted:2025-07-15 Online:2025-12-31 Published:2025-12-31
  • Contact: CHEN Liang-hua

摘要: 橘皮黄酮类成分可从芸香科植物橘Citrus reticulata及其栽培变种的成熟果皮中提取而来。橘皮黄酮类成分主要包括川陈皮素、橘皮素、橙皮苷、柚皮素等,具有抗炎、抗血栓、抗肿瘤、抗过敏以及心血管保护等药理活性。本文综述橘皮黄酮类成分对人体心脏保护作用及其机制的研究进展,围绕心肌缺血再灌注、心肌肥大、心律失常、心肌纤维化以及其他疾病或药物引起的心脏损伤等方面进行探讨,并展望其未来发展。

关键词: 橘皮黄酮, 心脏保护作用, 机制, 信号通路, 蛋白表达

Abstract: Citrus flavonoids are extracted from the mature peel of Citrus reticulata and its cultivated varieties. Flavonoids from citrus peel are mainly composed of nobiletin, tangerine, hesperidin and naringenin which have pharmacological effects such as anti-inflammatory, anti-thrombotic, anti-tumor, anti-allergic, and cardiovascular protection. This article reviews the research progress of citrus peel flavonoids on their cardio protective effects and mechanisms, focusing on five aspects: myocardial ischemia-reperfusion, cardiac hypertrophy, arrhythmia, myocardial fibrosis, and the damage of other diseases or drugs to the heart, and looks forward to their future development.

Key words: citrus peel flavonoids, cardio protection, mechanisms, signaling pathway, protein expression

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