关键词: 微核, 遗传毒理, 甲硝唑, 蚕豆根尖

Abstract: The effect that metronidazole induces the micronucleus of root tip cells in Vicia faba was mainly studied in this experimentation. By this study, it showed that: (1) When the metronidazole concentration was 0.1 mg/L, 6 mg/L, 12 mg/L, 40mg/L and 500 mg/L, the micronucleus frequencies of root tip cells in Vicia faba was significantly different from that of negative control group, and there was apparent dosage—effect relationship between the concentration of metronidazole and the micronucleus frequencies of root tip cells in Vicia faba；(2) Metronidazole could cause the damage of genetical materials (DNA), and it had the characteristic of molecular mutagenesis.

Key words: micronucleus, hereditary toxicity, metronidazole, root tip of Vicia faba