朝鲜蓟提取物颗粒剂的制备工艺研究

doi:10.3969/j.issn.1009-7791.2020.06.009

亚热带植物科学 ›› 2020, Vol. 49 ›› Issue (06): 458-463.DOI: 10.3969/j.issn.1009-7791.2020.06.009

• 植物生化与分子生物学 • 上一篇下一篇

朝鲜蓟提取物颗粒剂的制备工艺研究

汤须崇1*，卢绍基2，明艳林3，邓爱华4，牛文静1

(1.华侨大学化工学院，福建厦门 361021；2.厦门塔斯曼生物工程有限公司，福建厦门 361027；3.福建省亚热带植物研究所，福建厦门 361000；4.湖南文理学院生命与环境科学学院，湖南常德 415000)

收稿日期:2020-12-08 修回日期:2020-12-16 出版日期:2020-12-30 发布日期:2020-12-30
通讯作者: 汤须崇
基金资助:
2018年华侨大学产业孵化基金投资项目朝鲜蓟固体饮料研制及产业化资产(2018)17号；厦门市产学研协同创新项目(3502720173051)；湖南文理学院博士启动基金项目(17BSQD10)；湖南省自然科学基金(2017JJ4043)

The Preparation Technology of Artichoke Extract Granules

TANG Xu-chong ¹*, LU Shao-ji², MING Yan-lin³, DENG Ai-hua⁴, NIU Wen-jing¹

(1.College of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian China; 2.Xiamen Tasman Bio-Tech. Co., Ltd., Xiamen 361027, Fujian China; 3.Fujian Institute of Subtropical Botany, Xiamen 3610004, Fujian China; 4.College of Life and Environmental Sciences, Hunan University of Arts and Science, Changde 415000, Hunan China)

Received:2020-12-08 Revised:2020-12-16 Online:2020-12-30 Published:2020-12-30
Contact: TANG Xu-chong

摘要/Abstract

摘要： 以单因素试验为基础，采用正交实验设计优化制备朝鲜蓟(Cynara scolymus)提取物颗粒剂的最佳工艺条件。以原料与辅料配比、原料药比例、乙醇浓度及干燥温度为考察因素，以颗粒合格率、溶化时间作为评价指标，采用L₉(3⁴)正交试验分别对颗粒合格率、溶化时间进行直观分析及方差分析。结果表明，最佳成型工艺为乳糖:糊精=3:1，乙醇浓度60%，原料药比例7.0%，干燥温度50 ℃。按此方案进行验证实验，颗粒性状良好，颗粒合格率为91.45%，含水量4.90%，减失重量不超过2.0%，溶解时间85.67 s，均符合2020年中国药典有关规定。通过正交试验优选的颗粒剂制备工艺稳定、简便易行，为朝鲜蓟提取物的剂型开发及工业化生产颗粒剂提供理论依据。

关键词: 朝鲜蓟提取物, 颗粒剂, 制备工艺, 正交设计

Abstract: To optimize the preparation conditions of artichoke extract granules by orthogonal design based on single factor experiment, the ratio of raw materials and excipients, the ratio of raw materials, the concentration of ethanol and the drying temperature were taken as the investigation factors, the particle pass rate and dissolution time were taken as the evaluation indexes, and the orthogonal test of L9(34) was used to analyze the particle pass rate and dissolution time directly and anova respectively. The best molding process: lactose:dextrin=3:1, ethanol concentration was 60%, raw material ratio was 7.0%, and drying temperature was 50 ℃. According to the verification experiment of this scheme, the particle properties were good, the qualified rate of the particles was 91.45%, the water content was 4.90%, the weight loss didn’t exceed 2.0%, and the dissolution time was 85.67 s, which all met the Chinese Pharmacopoeia(2020) specifications. The preparation process of granules optimized by orthogonal test was proved to be stable and simple, which provided a theoretical basis for the research and development of dosage form of artichoke extract and mass production of granules in industry.

Key words: artichoke extract, granule, preparation process, orthogonal design

中图分类号:

R944.2

汤须崇，卢绍基，明艳林，邓爱华，牛文静 . 朝鲜蓟提取物颗粒剂的制备工艺研究[J]. 亚热带植物科学, 2020, 49(06): 458-463.

TANG Xu-chong, LU Shao-ji, MING Yan-lin, DENG Ai-hua, NIU Wen-jing. The Preparation Technology of Artichoke Extract Granules[J]. Subtropical Plant Science, 2020, 49(06): 458-463.

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朝鲜蓟提取物颗粒剂的制备工艺研究

The Preparation Technology of Artichoke Extract Granules

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