Research Progress on Chemical Constituents and Biological Activity of Nothapodytes nimmoniana

doi:10.3969/j.issn.1009-7791.2016.04.017

Subtropical Plant Science ›› 2016, Vol. 45 ›› Issue (04): 379-385.DOI: 10.3969/j.issn.1009-7791.2016.04.017

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Research Progress on Chemical Constituents and Biological Activity of Nothapodytes nimmoniana

SHEN Rui-chi,WU Mei-fang,HE En-ming,CHEN De-lin,WANG Jie,HE Jian-zhang,ZHOU Shuang

(Fujian Institute of Subtropical Botany, Fujian Key Laboratory of Physiology and Biochemistry for Subtropical Plant, Xiamen 361006, Fujian China)

Received:2016-05-24 Revised:2017-01-19 Online:2016-12-10 Published:2016-12-10
Contact: WU Mei-fang

青脆枝化学成分及其活性研究进展

沈瑞池,吴美芳,何恩铭,陈德林,王杰,何建章,周爽

(福建省亚热带植物研究所，福建省亚热带植物生理生化重点实验室，福建厦门 361006)

通讯作者: 吴美芳
作者简介:沈瑞池，硕士，副研究员，从事天然药物开发利用研究。
基金资助:
厦门市科技计划项目(3502Z20141041、3502Z20151245、3502Z20150057、3502Z20162010)；厦门市重大科技创新平台项目(3502Z20131004)；福建省亚热带植物研究所基金项目(2015S004、2015S005)

Abstract

Abstract: Camptothecin (CPT) is a cytotoxic quinoline alkaloid which is only one specially inhibiting the DNA enzyme topoisomerase I (topo I), showes remarkable anticancer activity. There are many CPTs and other active ingredients in Nothapodytes nimmoniana, the contents of CPT, 9-methoxycamptothecin and hydroxycamptothecin in Nothapodytes nimmoniana are most abundant. N. nimmoniana have become an important medicinal plant. In this paper, the chemical constituents, their biological activity and extraction methods of N. nimmoniana were summarized. In addition, the development and utilization prospect of N. nimmoniana were introduced.

Key words: Nothapodytes nimmoniana, camptothecin, chemical constituents, biological activity, extraction

摘要： 喜树碱是已发现的唯一专门通过抑制拓扑异构酶Ⅰ发挥细胞毒性的天然植物成分，具有广谱抗肿瘤活性。青脆枝Nothapodytes nimmoniana含有多种喜树碱类化合物及其他活性成分，其中喜树碱、9-甲氧基喜树碱和羟基喜树碱含量最为丰富，是重要的药用植物。文中综述青脆枝主要化学成分、生物活性及其提取方法，并对青脆枝的应用前景作展望。

关键词: 青脆枝, 喜树碱, 化学成分, 生物活性, 提取

CLC Number:

Q946.8

SHEN Rui-chi,WU Mei-fang,HE En-ming,CHEN De-lin,WANG Jie,HE Jian-zhang,ZHOU Shuang. Research Progress on Chemical Constituents and Biological Activity of Nothapodytes nimmoniana[J]. Subtropical Plant Science, 2016, 45(04): 379-385.

沈瑞池,吴美芳,何恩铭,陈德林,王杰,何建章,周爽. 青脆枝化学成分及其活性研究进展[J]. 亚热带植物科学, 2016, 45(04): 379-385.

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Research Progress on Chemical Constituents and Biological Activity of Nothapodytes nimmoniana

青脆枝化学成分及其活性研究进展

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