Research Advances on Extraction and Pharmacological Effects of Lily Saponins

doi:10.3969/j.issn.1009-7791.2022.03.012

Subtropical Plant Science ›› 2022, Vol. 51 ›› Issue (3): 233-240.DOI: 10.3969/j.issn.1009-7791.2022.03.012

• Review • Previous Articles

Research Advances on Extraction and Pharmacological Effects of Lily Saponins

ZHANG Yong-li1,2, CHEN Qing-zhi2, GENG Wen-hui1,2, WANG Hui-li3, DU Chong-wu3, MING Yan-lin1,2*

(1. College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian China; 2. Xiamen Overseas Chinese Subtropical Plant Introduction Garden / Plant Introduction & Quarantine and Plant Product Key Laboratory of Xiamen City, Xiamen 361002, Fujian China; 3. Linxia Academy of Agricultural Sciences, Linxia 731100, Gansu China)

Received:2022-03-25 Accepted:2022-06-01 Online:2022-06-30 Published:2022-10-17
Contact: MING Yan-lin

百合皂苷类化学成分提取及药理活性研究进展

张永莉1,2，陈清智2，耿文慧1,2，王慧莉3，杜崇武3，明艳林1,2*

(1. 福建农林大学食品科学学院，福建福州 350002；2. 厦门华侨亚热带植物引种园 / 厦门市植物引种检疫与植物源产物重点实验室，福建厦门 361002；3. 临夏州农业科学院，甘肃临夏 731100)

通讯作者: 明艳林
基金资助:
厦门市科技扶贫项目(3502Z20194520)；厦门市重大科技计划项目(3502Z20211006)

Abstract

Abstract: Lilium plants had rich chemical diversity, they had been the focus of natural product chemistry research in recent years. This review summarized the extraction methods, chemical components and pharmacological activities of lily saponins, so as to provide potential research ideas for the development and utilization of lily saponins.

Key words: Lily saponin, extraction process, pharmacological activity

摘要： 百合属植物化学成分多样，近年来成为天然产物化学研究的重点。文中着重对百合中重要化学成分百合皂苷的提取方法、化学成分及药理活性进行综述，为百合皂苷的开发利用提供参考。

关键词: 百合皂苷, 提取工艺, 药理活性

CLC Number:

S567.23

ZHANG Yong-li, CHEN Qing-zhi, GENG Wen-hui, WANG Hui-li, DU Chong-wu, MING Yan-lin. Research Advances on Extraction and Pharmacological Effects of Lily Saponins[J]. Subtropical Plant Science, 2022, 51(3): 233-240.

张永莉，陈清智，耿文慧，王慧莉，杜崇武，明艳林. 百合皂苷类化学成分提取及药理活性研究进展[J]. 亚热带植物科学, 2022, 51(3): 233-240.

References

[1] Liang S Y, Tamura M N. Lilium Linnaeus[M]// Wu Z Y, Raven P H. Flora of China. Beijing: Science Press & St. Louis: Missouri Botanical Garden, 2000: 135–149. [2] 国家药典委员会. 中华人民共和国药典(第1卷)[M]. 北京: 中国医药科技出版社, 2020. [3] 产祝龙, 程灵韵, 程玉华, 李绅崇, 王继华. 浅析百合的起源与历史文化[J]. 园艺与种苗, 2022, 42(2): 63–65. [4] 贺晓龙, 邵青, 姚尧, 王延峰, 张昊. 百合总皂甙提取方法的研究进展[J]. 南方农业, 2015(9): 122–123. [5] 张维西, 朱峰, 胡瑞, 张春辉. 百合总皂苷的现代研究进展[J]. 河北北方学院学报(自然科学版), 2017, 33(6): 42–43,46. [6] 吴晓斌, 任凤莲, 邱昌桂, 吴泓毅. 百合皂苷的提取、纯化及其鉴定[J]. 广州化学, 2005(2): 36–40. [7] 吉宏武, 丁霄霖. 百合总皂苷定量测定方法的研究[J]. 林产化学与工业, 2003(4): 54–58. [8] 何郁菲, 曾斌, 向阳, 蔡翔, 李恒彪. 水浴回流与超声波辅助回流提取百合皂苷工艺比较研究[J]. 天然产物研究与开发, 2014, 26(6): 895–901. [9] 潘青友. 百合渣中总皂苷的提取纯化与免疫活性研究[D]. 无锡: 江南大学硕士学位论文, 2013. [10] 张璐, 时伟, 张金玲. 超声酶法提取百合总皂苷的研究[J]. 饮料工业, 2012, 15(6): 20–22. [11] Hong X X, Luo J G, Guo C, Kong L. New steroidal saponins from the bulbs of Lilium brownii var. viridulum[J]. Carbohydrate Research, 2012, 361(none): 19–26. [12] Satou T, Mimaki Y, Kuroda M, Sashida Y, Hatakeyama Y. A pyrroline glucoside ester and steroidal saponins from Lilium martagon[J]. Phytochemistry, 1996, 41(4): 1225–1230. [13] Mimaki Y, Satou T, Kuroda M, Sashida Y, Hatakeyama Y. Steroidal saponins from the bulbs of Lilium candidum[J]. Phytochemistry, 1999, 51(4):567–573. [14] Mimaki Y, Nakamura O, Sashida Y, Satomi Y, Nishino A, Nishino H. Steroidal saponins from the bulbs of Lilium longiflorum and their antitumour-promoter activity[J]. Phytochemistry, 1994, 31(1): 221–232. [15] Mimaki Y, Satou T, Kuroda M, Sashida Y, Hatakeyama Y. New steroidal constituents from the bulbs of Lilium candidum[J]. Chemical & Pharmaceutical Bulletin, 1998, 46(11): 1829. [16] Mimaki Y, Sashida Y. Steroidal saponins from the bulbs of Lilium brownii[J]. Phytochemistry, 1990, 29(7): 2267–2271. [17] 杨秀伟, 吴云山, 崔育新, 刘雪辉, 肖诗鹰. 卷丹中新甾体皂苷的分离和鉴定[J]. 药学学报, 2002(11): 863–866. [18] Ori K, Mimaki Y, Mito T, Sashida Y, Nikaido T, Ohmoto T, Masuko A. Jatropham derivatives and steroidal saponins from the bulbs of Lilium hansonii[J]. Phytochemistry, 1992, 31(8): 2767–2775. [19] Shimomura H, Sashida Y, Mimaki Y. Steroidal saponins, pardarinoside A-G from the bulbs of Lilium pardarinum[J]. Phytochemistry, 1989, 28(11): 3163–3170. [20] Mimaki Y, Sashida Y. Sterodial saponins and alkaloids from the bulbs of Lilium brownii var. colchesteri[J]. Chemical and Pharmaceutical Bulletin, 1990, 38(11): 3055–3059. [21] Munafo J P, Ramanathan A, Jimenez L S, Gianfagna T J. Isolation and structural determination of steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.)[J]. Journal of Agricultural & Food Chemistry, 2010, 58(15): 8806–8813. [22] 周中流, 石任兵, 刘斌, 王雪梅. 卷丹化学成分的研究[J]. 北京中医药大学学报, 2010(1): 57–61. [23] 周中流, 石任兵, 刘斌, 邹节明, 尹文清. 卷丹甾体皂苷和酚类成分及其抗氧化活性研究[J]. 中草药, 2011(1): 21–24. [24] 胡文彦, 段金廒, 钱大玮, 王大为. 卷丹化学成分研究[J]. 中国中药杂志, 2007, 32(16): 1656–1659. [25] 周中流,石任兵, 刘斌, 夏敬民, 尹文清. 一种百合甾体皂苷纯度及糖链结构核磁共振法分析[J]. 天然产物研究与开发, 2012, 24(3): 307–311. [26] Nakamura O, Mimaki Y, Nishino H, Sashida Y. Steroidal saponins from the bulbs of Lilium speciosum × L. nobilissimum 'Star Gazer' and their antitumour-promoter activity[J]. 1994, 36(2): 463–467. [27] Thi N N, Lee Y G, Seo K, Kim H G, Lee D Y, Baek N. New furospirostane steroidal saponins from the flowers of Lilium asiatic hybrids[J]. Carbohydrate Research, 2019, 481:36–42. [28] Tokgun O, Akca H, Mammadov R, Aykurt C, Gokhan D. Convolvulus galaticus, Crocus antalyensis, and Lilium candidum extracts show their antitumor activity through induction of p53-mediated apoptosis on human breast cancer cell line MCF-7 cells[J]. Journal of medicinal food, 2012, 15(11): 1000–1005. [29] 雷卢恒. 卷丹百合不同居群鳞茎提取物的抗氧化及肺癌细胞抑制特性研究[D]. 杨凌: 西北农林科技大学硕士学位论文, 2015. [30] 罗林明, 覃丽, 詹济华, 裴刚, 周小江. 百合总皂苷对肺癌细胞增殖、凋亡及侵袭转移的作用及其初步机制研究[J]. 中国中药杂志, 2018, 43(22): 4498–4505. [31] 贾蕾. 百合对人胃癌SGC-7901细胞的增殖抑制作用及其机制的探讨[D]. 延安: 延安大学硕士学位论文, 2015. [32] Zhang Y Y, Luo L M, Wang Y X, Zhu N, Zhao T J, Qin L. Total saponins from Lilium lancifolium: a promising alternative to inhibit the growth of gastric carcinoma cells[J]. Journal of Cancer, 2020, 11(14), 4261–4273. [33] Silva C I, Gon?alves-de-Albuquerque C F, de Moraes B P T. Na/K-ATPase: Their role in cell adhesion and migration in cancer[J]. Biochimie, 2021, 185: 1–8. [34] 刘晶, 陈复辉, 陈淑芳. 钠钾ATP酶的临床研究进展[J]. 现代医学, 2016(6): 4. [35] Zhou Z L, Feng Z C, Fu C, Zhang H L, Xia J M. Steroidal and Phenolic Glycosides from the Bulbs of Lilium pumilum DC and Their Potential Na+/K+ ATPase Inhibitory Activity[J]. Molecules, 2012, 17(9): 10494–10502. [36] 霍桂桃, 霍艳颖, 李佳, 陈武, 姜代勋. 中药通过cAMP–磷酸二酯酶介导的信号调节炎症(英文)[J]. 生物化学与生物物理进展, 2020, 47(8): 659–674. [37] Nakamura O, Nikaido T, Ohmoto T. Steroidal saponins from the bulbs of Lilium regale and L. henryi[J]. Pergamon, 1993, 33(3): 675–682. [38] 王瑛. 百合皂苷的提取工艺与抗抑郁作用研究[J]. 中国药房, 2014, 25(7): 602–604. [39] 郭秋平. 百合的质量研究及抗抑郁作用探讨[D]. 广州: 广州中医药大学硕士学位论文, 2009. [40] 何丹, 黄建华, 曾宏亮, 黄小龙, 舒骏. 基于网络药理学的百合抗抑郁作用机制研究[J]. 中国现代中药, 2020, 22(12): 1996–2005. [41] 李海龙, 高淑怡, 高英, 荣向路, 李为民. 百合知母总皂苷镇静催眠的药效学研究[J]. 北方药学, 2012, 9(10): 34–35. [42] Esposito D, Munafo J P, Teresa L, Baldeon M, Komarnytsky S, Gianfagna T. Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro[J]. Journal of Ethnopharmacology, 2013, 148(2): 433–440. [43] 吴晓斌, 任凤莲, 邱昌桂, 李彤, 吴泓毅. 百合皂苷的提取、纯化及其对自由基的清除作用[J]. 天然产物研究与开发, 2005(6): 777–780. [44] Beck A T, Clark D A. Anxiety and depression: An information processing perspective[J]. Anxiety Stress & Coping, 1988, 1(1): 23–36. [45] 王琳, 张兴军, 金黎明, 杨鸿均. 抗抑郁药物的研究进展[J]. 化学世界, 2022, 63(2): 83–93. [46] 裴斯彪, 王丹, 殷文. 地奥心血康软胶囊对冠心病介入术后心绞痛及血清脂质过氧化物的影响[J]. 药物评价研究, 2019(5): 912–916.

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Research Advances on Extraction and Pharmacological Effects of Lily Saponins

百合皂苷类化学成分提取及药理活性研究进展

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